Title : Nucleoside Reverse Transcriptase Inhibitor Interaction with Human Equilibrative Nucleoside Transporters 1 and 2.

Pub. Date : 2020 Jul

PMID : 32393653






2 Functional Relationships(s)
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1 Inhibition of [3H]uridine uptake by NBMPR was biphasic, with IC50 values of 11.3 nM for ENT1 and 9.6 muM for ENT2. Uridine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 The resulting five-fold difference in intrinsic clearance (Jmax/Kt) for ENT1- and ENT2 transport accounted for observed inhibition of [[3H]uridine uptake by 100 nM NBMPR. Uridine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens