Pub. Date : 2020 May 7
PMID : 32392809
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective Degradation Permits a Feedback Loop Controlling Annexin A6 and Cholesterol Levels in Endolysosomes of NPC1 Mutant Cells. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | Two KFERQ-motifs are believed to target AnxA6 to lysosomes for chaperone-mediated autophagy (CMA), and we hypothesized that the cholesterol accumulation in endolysosomes (LE/Lys) triggered by the NPC1 inhibition could interfere with the CMA pathway. | Cholesterol | NPC intracellular cholesterol transporter 1 | Homo sapiens |