Title : Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model.

Pub. Date : 2020 Aug 1

PMID : 32389830






2 Functional Relationships(s)
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1 Additionally, metformin could affect the interactions of ZO-1 with p-Src/Cx43 via decrease the abnormal cAMP level after pacing (84.04 +- 4.58 vs. 69.34 +- 4.5 nmol/L, P<0.001). Metformin SRC proto-oncogene, non-receptor tyrosine kinase Canis lupus familiaris
2 CONCLUSIONS: Metformin could alleviate the vulnerability of AF and attenuate the downregulation of gap junction under pacing condition via AMPK pathway and decreasing the P-Src level. Metformin SRC proto-oncogene, non-receptor tyrosine kinase Canis lupus familiaris