Pub. Date : 2020 Jun 26
PMID : 32376690
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that polyamines stimulate the translation of histone acetyltransferases GCN5 and HAT1. | Polyamines | K(lysine) acetyltransferase 2A | Mus musculus |
| 2 | Accordingly, GCN5- and HAT1-catalyzed acetylation of specific lysine residues on histones H3 and H4 was stimulated by polyamines. | Polyamines | K(lysine) acetyltransferase 2A | Mus musculus |
| 3 | These results indicate that polyamines regulate gene expression by enhancing the expression of the histone acetyltransferases GCN5 and HAT1 at the level of translation. | Polyamines | K(lysine) acetyltransferase 2A | Mus musculus |
| 4 | Mechanistically, polyamines enhanced the interaction of microRNA-7648-5p (miR-7648-5p) with the 5"-UTR of GCN5 mRNA, resulting in stimulation of translation due to the destabilization of the double-stranded RNA (dsRNA) between the 5"-UTR and the ORF of GCN5 mRNA. | Polyamines | K(lysine) acetyltransferase 2A | Mus musculus |
| 5 | Mechanistically, polyamines enhanced the interaction of microRNA-7648-5p (miR-7648-5p) with the 5"-UTR of GCN5 mRNA, resulting in stimulation of translation due to the destabilization of the double-stranded RNA (dsRNA) between the 5"-UTR and the ORF of GCN5 mRNA. | Polyamines | K(lysine) acetyltransferase 2A | Mus musculus |