Pub. Date : 2020 Jul
PMID : 32350062
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2A6 is responsible for the metabolism of nicotine and several other xenobiotics, but its susceptibility to down-regulation by NO has not been reported. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | SIGNIFICANCE STATEMENT: This study demonstrates that the nicotine metabolizing enzyme CYP2A6 is down regulated by nitric oxide, a molecule produced in large amounts in the context of inflammation and that is also inhaled from cigarette smoke. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |