Pub. Date : 2020 Apr 27
PMID : 32349283
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner. | Fingolimod Hydrochloride | brain derived neurotrophic factor | Mus musculus |
| 2 | Among the different therapeutic strategies developed to improve endogenous BDNF levels is the administration of the BDNF-inducing drug Fingolimod, an agonist of the sphingosine-1-phosphate receptor. | Fingolimod Hydrochloride | brain derived neurotrophic factor | Mus musculus |
| 3 | Among the different therapeutic strategies developed to improve endogenous BDNF levels is the administration of the BDNF-inducing drug Fingolimod, an agonist of the sphingosine-1-phosphate receptor. | Fingolimod Hydrochloride | brain derived neurotrophic factor | Mus musculus |
| 4 | However, the cellular mechanisms through which Fingolimod mediates its BDNF-dependent therapeutic effects remain unclear. | Fingolimod Hydrochloride | brain derived neurotrophic factor | Mus musculus |
| 5 | Importantly, we show that BDNF release is required for these actions of Fingolimod. | Fingolimod Hydrochloride | brain derived neurotrophic factor | Mus musculus |
| 6 | Our study provides insights into understanding the BDNF-dependent therapeutic actions of Fingolimod. | Fingolimod Hydrochloride | brain derived neurotrophic factor | Mus musculus |