Pub. Date : 2020 Dec
PMID : 32345117
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Long non-coding RNA H19 regulates proliferation and Doxorubicin resistance in MCF-7 cells by targeting PARP1. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 2 | The long noncoding RNA H19 (H19) is involved in various stages of tumorigenesis, however, its role in doxorubicin resistance remains unknown. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 3 | The long noncoding RNA H19 (H19) is involved in various stages of tumorigenesis, however, its role in doxorubicin resistance remains unknown. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 4 | The goal of this study was to evaluate the role of H19 in the development of doxorubicin-resistant breast cancer. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 5 | Both knockdown and overexpression of H19 were used to assess the sensitivity to doxorubicin in breast cancer cells in vitro and in vivo. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 6 | qRT-PCR and Western blot were used to explore the doxorubicin resistance mechanism of H19. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 7 | We observed that the H19 expression was significantly upregulated in chemotherapy-resistant breast cancer tissues and doxorubicin-resistant breast cancer cell lines. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 8 | Knockdown of H19 enhanced the sensitivity to doxorubicin both in vitro and in vivo. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 9 | While H19 overexpression developed doxorubicin-resistant in breast cancer cells both in vitro and in vivo. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 10 | Furthermore, it was revealed that H19 negatively regulated PARP1 expression in breast cancer cells following doxorubicin treatment. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 11 | Knockdown of H19 sensitized breast cancer cells to doxorubicin by promoting PARP1 upregulation. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |
| 12 | H19 overexpression could recapitulate doxorubicin resistance by PARP1 downregulation. | Doxorubicin | H19 imprinted maternally expressed transcript | Homo sapiens |