Pub. Date : 2020 Apr 25
PMID : 32344880
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma. | Nelfinavir | NFE2 like bZIP transcription factor 1 | Homo sapiens |
| 2 | Here, we describe how nelfinavir inhibits the TCF11/Nrf1-driven recovery pathway by a dual mode of action. | Nelfinavir | NFE2 like bZIP transcription factor 1 | Homo sapiens |
| 3 | Nelfinavir decreases the total protein level of TCF11/Nrf1 and inhibits TCF11/Nrf1 proteolytic processing, likely by interfering with the DDI2 protease, and therefore reduces the TCF11/Nrf1 protein level in the nucleus. | Nelfinavir | NFE2 like bZIP transcription factor 1 | Homo sapiens |
| 4 | Nelfinavir decreases the total protein level of TCF11/Nrf1 and inhibits TCF11/Nrf1 proteolytic processing, likely by interfering with the DDI2 protease, and therefore reduces the TCF11/Nrf1 protein level in the nucleus. | Nelfinavir | NFE2 like bZIP transcription factor 1 | Homo sapiens |
| 5 | Nelfinavir decreases the total protein level of TCF11/Nrf1 and inhibits TCF11/Nrf1 proteolytic processing, likely by interfering with the DDI2 protease, and therefore reduces the TCF11/Nrf1 protein level in the nucleus. | Nelfinavir | NFE2 like bZIP transcription factor 1 | Homo sapiens |