Pub. Date : 2020 Apr 24
PMID : 32344513
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A key cellular factor that contributes to sensitivity to platinums is the 5"-3" structure-specific endonuclease excision repair cross-complementation group 1 (ERCC1)/ xeroderma pigmentosum group F (XPF). | Platinum | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 2 | ERCC1/XPF is critical for the repair of platinum-induced DNA damage and has been the subject of intense research efforts to identify small molecule inhibitors of its nuclease activity for the purpose of enhancing patient response to platinum-based chemotherapy. | Platinum | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
| 3 | ERCC1/XPF is critical for the repair of platinum-induced DNA damage and has been the subject of intense research efforts to identify small molecule inhibitors of its nuclease activity for the purpose of enhancing patient response to platinum-based chemotherapy. | Platinum | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |