Pub. Date : 2020 May
PMID : 32330868
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway. | Metformin | gasdermin D | Homo sapiens |
| 2 | Importantly, Metformin reduced pyroptosis-related proteins, including NLRP3, cleaved caspase-1, and the N-terminus of GSDMD. | Metformin | gasdermin D | Homo sapiens |
| 3 | Knocking down the GSDMD could reversed the protective effects of Metformin, which showed pyroptosis was one of the major cell death pathways controlled by Metformin treatment in setting of intestinal I/R injury. | Metformin | gasdermin D | Homo sapiens |
| 4 | Knocking down the GSDMD could reversed the protective effects of Metformin, which showed pyroptosis was one of the major cell death pathways controlled by Metformin treatment in setting of intestinal I/R injury. | Metformin | gasdermin D | Homo sapiens |
| 5 | In conclusion, we believe that Metformin protects against intestinal I/R injury in a TXNIP-NLRP3-GSDMD-dependent manner. | Metformin | gasdermin D | Homo sapiens |