Title : Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity.

Pub. Date : 2020 Jul 1

PMID : 32325220






1 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Antibody drug conjugates targeting DPEP3 have shown efficacy in preclinical models with a pyrrolobenzodiazepine conjugate, SC-003, dosed in a phase I clinical trial (NCT02539719). sc-003 dipeptidase 3 Homo sapiens