Pub. Date : 2020 Jul 1
PMID : 32325220
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, DPEP3 diverges from DPEP1 and DPEP2 in key positions of its active site: a histidine to tyrosine variation at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance, whereas an aspartate to asparagine change at position 359 abolishes activation of the nucleophilic water/hydroxide, resulting in no in vitro activity against a variety of dipeptides and biological substrates (imipenem, leukotriene D4 and cystinyl-bis-glycine). | Dipeptides | dipeptidase 1 | Homo sapiens |