Pub. Date : 2020 Apr
PMID : 32323781
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MicroRNA-22 mediates the cisplatin resistance of osteosarcoma cells by inhibiting autophagy via the PI3K/Akt/mTOR pathway. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The aim of the present study was therefore to investigate whether miR-22 could mediate the CDDP resistance of OS cells by inhibiting autophagy via the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | miR-22 mediated the CDDP resistance of OS cells by inhibiting autophagy and decreasing CDDP-induced autophagy via downregulation of the expression of PI3K, Akt, and mTOR at the mRNA level, and the expression of PI3K, phosphorylated (p)-Akt, and p-mTOR at the protein level. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | miR-22 mediated the CDDP resistance of OS cells by inhibiting autophagy and decreasing CDDP-induced autophagy via downregulation of the expression of PI3K, Akt, and mTOR at the mRNA level, and the expression of PI3K, phosphorylated (p)-Akt, and p-mTOR at the protein level. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | miR-22 mediated the CDDP resistance of OS cells by inhibiting autophagy and decreasing CDDP-induced autophagy via downregulation of the expression of PI3K, Akt, and mTOR at the mRNA level, and the expression of PI3K, phosphorylated (p)-Akt, and p-mTOR at the protein level. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | miR-22 mediated the CDDP resistance of OS cells by inhibiting autophagy and decreasing CDDP-induced autophagy via downregulation of the expression of PI3K, Akt, and mTOR at the mRNA level, and the expression of PI3K, phosphorylated (p)-Akt, and p-mTOR at the protein level. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | It was also convincingly demonstrated that miR-22 mediates the CDDP resistance of OS by inhibiting autophagy via the PI3K/Akt/mTOR pathway. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 8 | Interestingly, CDDP was demonstrated to induce autophagy by inhibiting the PI3K/Akt/mTOR pathway, whereas the pathway was upregulated in the state of chemoresistance. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |