Pub. Date : 2020
PMID : 32322578
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Exosome-Derived miR-486-5p Regulates Cell Cycle, Proliferation and Metastasis in Lung Adenocarcinoma via Targeting NEK2. | mir-486-5p | NIMA (never in mitosis gene a)-related expressed kinase 2 | Mus musculus |
| 2 | Moreover, NEK2 was identified as a target of miR-486-5p both in vivo and in vitro. | mir-486-5p | NIMA (never in mitosis gene a)-related expressed kinase 2 | Mus musculus |
| 3 | Furthermore, rescue experiments indicated that the inhibitory effect of miR-486-5p overexpression on LUAD progression could be abrogated when miR-486-5p and NEK2 were simultaneously up-regulated. | mir-486-5p | NIMA (never in mitosis gene a)-related expressed kinase 2 | Mus musculus |
| 4 | Conclusion: Exosome-derived miR-486-5p is responsible for cell cycle arrest as well as the inhibition of cell proliferation and metastasis in LUAD via targeting NEK2. | mir-486-5p | NIMA (never in mitosis gene a)-related expressed kinase 2 | Mus musculus |