Pub. Date : 2020 Jun 19
PMID : 32321856
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The x-ray crystal structures of SARS-CoV-2 Mpro in complex with 11a or 11b, both determined at a resolution of 1.5 angstroms, showed that the aldehyde groups of 11a and 11b are covalently bound to cysteine 145 of Mpro Both compounds showed good pharmacokinetic properties in vivo, and 11a also exhibited low toxicity, which suggests that these compounds are promising drug candidates. | Aldehydes | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |
2 | The x-ray crystal structures of SARS-CoV-2 Mpro in complex with 11a or 11b, both determined at a resolution of 1.5 angstroms, showed that the aldehyde groups of 11a and 11b are covalently bound to cysteine 145 of Mpro Both compounds showed good pharmacokinetic properties in vivo, and 11a also exhibited low toxicity, which suggests that these compounds are promising drug candidates. | Aldehydes | NEWENTRY | Severe acute respiratory syndrome-related coronavirus |