Title : Clinically Relevant Cytochrome P450 3A4 Induction Mechanisms and Drug Screening in Three-Dimensional Spheroid Cultures of Primary Human Hepatocytes.

Pub. Date : 2020 Oct

PMID : 32320483






1 Functional Relationships(s)
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1 Rifampicin requires solely PXR to induce CYP3A4 and CYP2B6, while phenobarbital-mediated induction of these CYPs did not show absolute dependency on either PXR or CAR suggesting its ability to switch nuclear receptor activation. Rifampin cytochrome P450 family 2 subfamily B member 6 Homo sapiens