Pub. Date : 2020 May
PMID : 32319553
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Suppression of Musashi-2 by the small compound largazole exerts inhibitory effects on malignant cells. | largazole | musashi RNA binding protein 2 | Homo sapiens |
| 2 | Molecular docking analysis demonstrated that the small compound largazole binds to and may be a potential inhibitor of MSI2. | largazole | musashi RNA binding protein 2 | Homo sapiens |
| 3 | Largazole markedly decreased the protein and mRNA levels of MSI2 and suppressed its downstream mammalian target of rapamycin signaling pathway. | largazole | musashi RNA binding protein 2 | Homo sapiens |
| 4 | These results indicate that MSI2 is an emerging therapeutic target for NSCLC and CML, and the MSI2 inhibitor largazole may hold promise as a treatment for these malignancies. | largazole | musashi RNA binding protein 2 | Homo sapiens |