Pub. Date : 2020
PMID : 32318339
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of FEN1 Increases Arsenic Trioxide-Induced ROS Accumulation and Cell Death: Novel Therapeutic Potential for Triple Negative Breast Cancer. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 2 | The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision repair (BER) pathway, could improve the anti-tumor effect of arsenic trioxide (ATO), which is a reactive oxygen species (ROS) inducer. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 3 | The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision repair (BER) pathway, could improve the anti-tumor effect of arsenic trioxide (ATO), which is a reactive oxygen species (ROS) inducer. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 4 | The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision repair (BER) pathway, could improve the anti-tumor effect of arsenic trioxide (ATO), which is a reactive oxygen species (ROS) inducer. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 5 | The following study investigated whether the inhibition of Flap Endonuclease 1 (FEN1) expression, the key enzyme in the base excision repair (BER) pathway, could improve the anti-tumor effect of arsenic trioxide (ATO), which is a reactive oxygen species (ROS) inducer. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 6 | Our data showed that ATO could increase the expression of FEN1, and the knockdown of FEN1 could significantly enhance the sensitivity of TNBC cells to ATO both in vitro and in vivo. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 7 | Our data showed that ATO could increase the expression of FEN1, and the knockdown of FEN1 could significantly enhance the sensitivity of TNBC cells to ATO both in vitro and in vivo. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 8 | FEN1 knockdown can effectively decrease the application concentrations of ATO, thus providing a possibility for the treatment of TNBC with ATO. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |
| 9 | FEN1 knockdown can effectively decrease the application concentrations of ATO, thus providing a possibility for the treatment of TNBC with ATO. | Arsenic Trioxide | flap structure-specific endonuclease 1 | Homo sapiens |