Title : Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent.

Pub. Date : 2020 Apr 17

PMID : 32316587






5 Functional Relationships(s)
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1 Marathon Run-induced Changes in the Erythropoietin-Erythroferrone-Hepcidin Axis are Iron Dependent. Iron erythropoietin Homo sapiens
2 EPO, ERFE and Hpc biosynthesis is modified by serum iron through transferrin receptor 2. Iron erythropoietin Homo sapiens
3 In athletes whose serum iron levels were below 105 microg/day (n = 15), serum EPO (p = 0.00) and ERFE levels (p = 0.00) increased with no changes in Hpc concentration. Iron erythropoietin Homo sapiens
4 This indicates modulation of blood iron may affect exercise-induced changes in the EPO/ERFE/Hpc axis. Iron erythropoietin Homo sapiens
5 Further study is needed to fully understand the physiological meaning of the interdependence between iron and the EPO/ERFE/Hpc axis. Iron erythropoietin Homo sapiens