Title : Deletion of P2X7 Receptor Decreases Basal Glutathione Level by Changing Glutamate-Glutamine Cycle and Neutral Amino Acid Transporters.

Pub. Date : 2020 Apr 16

PMID : 32316268






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 SIN-1 (500 muM, a generator nitric oxide, superoxide and peroxynitrite), which facilitates the cystine-cysteine shuttle mediated by xCT (a glutamate/cystein:cystine/NAC antiporter), did not affect basal GSH concentration in WT and P2X7R knockout (KO) mice. Acetylcysteine mitogen-activated protein kinase associated protein 1 Mus musculus
2 However, SIN-1 effectively reduced the efficacy of NAC in GSH synthesis in WT mice, but not in P2X7R KO mice. Acetylcysteine mitogen-activated protein kinase associated protein 1 Mus musculus