Pub. Date : 2020 May 5
PMID : 32312817
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Triptolide suppresses IDH1-mutated malignancy via Nrf2-driven glutathione metabolism. | triptolide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Our findings showed that triptolide, a diterpenoid epoxide from Tripterygium wilfordii, served as a potent Nrf2 inhibitor, which exhibited selective cytotoxicity to patient-derived IDH1-mutated glioma cells in vitro and in vivo. | triptolide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | Mechanistically, triptolide compromised the expression of GCLC, GCLM, and SLC7A11, which disrupted glutathione metabolism and established synthetic lethality with reactive oxygen species derived from IDH1 mutant neomorphic activity. | triptolide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | Our findings highlight triptolide as a valuable therapeutic approach for IDH1-mutated malignancies by targeting the Nrf2-driven glutathione synthesis pathway. | triptolide | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |