Pub. Date : 2020 May 5
PMID : 32312817
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our present study demonstrated that IDH1-mutated cells showed elevated levels of reactive oxygen species and higher demands on Nrf2-guided glutathione de novo synthesis. | Reactive Oxygen Species | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | Mechanistically, triptolide compromised the expression of GCLC, GCLM, and SLC7A11, which disrupted glutathione metabolism and established synthetic lethality with reactive oxygen species derived from IDH1 mutant neomorphic activity. | Reactive Oxygen Species | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |