Title : Inhibition of Excision of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.

Pub. Date : 2020 May 12

PMID : 32302101






2 Functional Relationships(s)
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Protein Name
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1 The primary factor that recognizes DNA lesions is the DNA damage-sensing factor XPC-RAD23B (XPC), while the glycosylase NEIL1 is known to remove Gh and Sp lesions from double-stranded DNA. spiroiminodihydantoin nei like DNA glycosylase 1 Homo sapiens
2 These slow kinetics are attributed to the dissociation of XPC-DNA complexes that allow for the rebinding of NEIL1 to the temporarily exposed Gh or Sp lesions, and the incisions observed under these steady-state conditions. spiroiminodihydantoin nei like DNA glycosylase 1 Homo sapiens