Title : Long-term intake of the reactive metabolite methylglyoxal is not toxic in mice.

Pub. Date : 2020 Jul

PMID : 32298726






2 Functional Relationships(s)
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1 Mice simultaneously deficient in the receptor for AGEs (RAGE) and overexpressing Glo1 exhibited higher basal plasma MG levels and did generally not respond to long-term MG intake. Pyruvaldehyde glyoxalase 1 Mus musculus
2 In vitro experiments supported the minor relevance of Glo1 in the detoxification of circulating MG but the important role of plasma albumin as an MG scavenger. Pyruvaldehyde glyoxalase 1 Mus musculus