Pub. Date : 2020 Apr
PMID : 32295440
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BSC2 enhances cell resistance to AmB by inhibiting oxidative damage in Saccharomyces cerevisiae. | Amphotericin B | Bsc2p | Saccharomyces cerevisiae S288C |
| 2 | Previous study has shown that Saccharomyces cerevisiae strain lack of BSC2 was sensitive significantly to Amphotericin B. | Amphotericin B | Bsc2p | Saccharomyces cerevisiae S288C |
| 3 | In the present study, the role of BSC2 on Amphotericin B resistance were investigated. | Amphotericin B | Bsc2p | Saccharomyces cerevisiae S288C |
| 4 | We found that BSC2 enhanced the resistance of yeast cells to Amphotericin B, which was not related to cellular ergosterol content. | Amphotericin B | Bsc2p | Saccharomyces cerevisiae S288C |
| 5 | Taken together, BSC2 inhibits oxidative damage induced by Amphotericin B through increasing activities of antioxidant enzymes and levels of GSH to alleviate the accumulation of reactive oxygen species, lipid peroxidation and superoxide radical, resulting in the maintenance of mitochondrial membrane potential and cell membrane integrity. | Amphotericin B | Bsc2p | Saccharomyces cerevisiae S288C |
| 6 | However, Amphotericin B resistance mediated by BSC2 is independent of Yap1p, GSH1 and Hog1p. | Amphotericin B | Bsc2p | Saccharomyces cerevisiae S288C |
| 7 | The results demonstrate for the first time that BSC2 enhances cell resistance to Amphotericin B by inhibiting oxidative damage in yeast. | Amphotericin B | Bsc2p | Saccharomyces cerevisiae S288C |