Pub. Date : 2020
PMID : 32280245
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Results: Cisplatin attenuated the promoting capacity of CAFs on lung cancer cell migration and invasion, via suppressing CAFs" effect on metastasis-related genes including Twist1, vascular endothelial growth factor receptor (VEGFR), MMP2, and AKT signaling pathway. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | KRT8 upregulation in CAFs is responsible for the inhibitory effect of cisplatin on lung cancer cells metastasis potential through AKT pathway suppression. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | Conclusion: Our results revealed a novel mechanism that cisplatin attenuated the metastasis promoting effect of CAFs via KRT8/AKT signaling pathway. | Cisplatin | thymoma viral proto-oncogene 1 | Mus musculus |