Pub. Date : 2020 Apr 9
PMID : 32273511
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. | Aspartic Acid | tumor protein p53 | Homo sapiens |
| 2 | Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS expression and disrupts asparagine-aspartate homeostasis, leading to lymphoma and colon tumour growth inhibition in vivo and in vitro. | Aspartic Acid | tumor protein p53 | Homo sapiens |
| 3 | Mechanistically, asparagine and aspartate regulate AMPK-mediated p53 activation by physically binding to LKB1 and oppositely modulating LKB1 activity. | Aspartic Acid | tumor protein p53 | Homo sapiens |
| 4 | Thus, we found that p53 regulates asparagine metabolism and dictates cell survival by generating an auto-amplification loop via asparagine-aspartate-mediated LKB1-AMPK signalling. | Aspartic Acid | tumor protein p53 | Homo sapiens |