Pub. Date : 2020 Jul
PMID : 32272228
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations. | Calcium | transient receptor potential cation channel subfamily V member 4 | Homo sapiens |
| 2 | We have recently shown that the osteocyte responds to fluid shear stress via the microtubule network-dependent activation of NADPH oxidase 2 (NOX2)-generated reactive oxygen species and subsequent opening of TRPV4 cation channels, leading to calcium influx, activation of CaMKII, and rapid sclerostin protein downregulation. | Calcium | transient receptor potential cation channel subfamily V member 4 | Homo sapiens |
| 3 | Here, we showed that NOX2 and TRPV4-dependent calcium influx is required for calcium oscillations, and that TRPV4 activation is both necessary and sufficient for sclerostin degradation. | Calcium | transient receptor potential cation channel subfamily V member 4 | Homo sapiens |
| 4 | Here, we showed that NOX2 and TRPV4-dependent calcium influx is required for calcium oscillations, and that TRPV4 activation is both necessary and sufficient for sclerostin degradation. | Calcium | transient receptor potential cation channel subfamily V member 4 | Homo sapiens |