Title : Carboplatin-loaded SMNDs to reduce GSH-mediated platinum resistance for prostate cancer therapy.

Pub. Date : 2018 Nov 21

PMID : 32254583






4 Functional Relationships(s)
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1 Herein, a novel SMND of carboplatin-lauric acid nanoparticles (CBP-LA NPs) was developed for the first time to reduce GSH-mediated platinum resistance and improve the antitumor efficiency of platinum(ii). Platinum CREB binding protein Homo sapiens
2 Herein, a novel SMND of carboplatin-lauric acid nanoparticles (CBP-LA NPs) was developed for the first time to reduce GSH-mediated platinum resistance and improve the antitumor efficiency of platinum(ii). Platinum CREB binding protein Homo sapiens
3 The intracellular glutathione determination and the Pt-DNA adduct assay revealed that CBP-LA NPs could reduce the intracellular GSH levels and improve the efficiency of platinum chelating with DNA, which would overcome GSH-mediated platinum(ii) resistance. Platinum CREB binding protein Homo sapiens
4 The intracellular glutathione determination and the Pt-DNA adduct assay revealed that CBP-LA NPs could reduce the intracellular GSH levels and improve the efficiency of platinum chelating with DNA, which would overcome GSH-mediated platinum(ii) resistance. Platinum CREB binding protein Homo sapiens