Title : Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies.

Pub. Date : 2020 Jun

PMID : 32252002






2 Functional Relationships(s)
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1 Clinical studies show that the natural product fumagillin, and its analogs are potential inhibitors of MetAP2. fumagillin methionyl aminopeptidase 2 Homo sapiens
2 Taken together, these uninherited-fumagillin compounds may serve as new class of inhibitors or provide scaffolds for further optimization towards the design of more potent MetAP2 inhibitors -development of such inhibitors would be essential strategy against various cancer types. fumagillin methionyl aminopeptidase 2 Homo sapiens