Pub. Date : 2020 Jun
PMID : 32249133
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When [14C]creatine was accumulated in the cells with the aid of SLC6A8/CRT1, a concentrative creatine transporter, followed by assessing the remaining intracellular [14C]creatine after initiating efflux, coexpression of MCT12 resulted in a decrease in the intracellular [14C]creatine and remarkably enhanced the efflux of [14C]creatine from the cells in a time-dependent manner. | Creatine | solute carrier family 16 member 12 | Homo sapiens |
| 2 | The creatine efflux activity involved dissipation by the mutations of conserved charged amino acids such as Arg37, Asp65 and Asp299 in the transmembrane domains, indicating direct involvement of MCT12 in the creatine efflux. | Creatine | solute carrier family 16 member 12 | Homo sapiens |
| 3 | The creatine efflux activity involved dissipation by the mutations of conserved charged amino acids such as Arg37, Asp65 and Asp299 in the transmembrane domains, indicating direct involvement of MCT12 in the creatine efflux. | Creatine | solute carrier family 16 member 12 | Homo sapiens |
| 4 | These results suggest that MCT12 mediates facilitative diffusion of creatine, depending on the concentration gradient across the plasma membrane in mammalian cells. | Creatine | solute carrier family 16 member 12 | Homo sapiens |