Title : Wnt signaling regulates neural plate patterning in distinct temporal phases with dynamic transcriptional outputs.

Pub. Date : 2020 Jun 15

PMID : 32243887






3 Functional Relationships(s)
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1 A major outcome of these Wnt signaling phases is the specification of the major compartment divisions of the developing brain: first the MHB, then the diencephalic-mesencephalic boundary (DMB). dmb wingless-type MMTV integration site family, member 8b Danio rerio
2 We suggest that the change in otx2b response to Wnt regulation enables a transition to the mes/r1 phase of Wnt-mediated patterning, as it ensures that Wnts expressed in the midbrain and MHB do not suppress midbrain identity, and consequently reinforce formation of the DMB. dmb wingless-type MMTV integration site family, member 8b Danio rerio
3 We suggest that the change in otx2b response to Wnt regulation enables a transition to the mes/r1 phase of Wnt-mediated patterning, as it ensures that Wnts expressed in the midbrain and MHB do not suppress midbrain identity, and consequently reinforce formation of the DMB. dmb wingless-type MMTV integration site family, member 8b Danio rerio