Title : Quantitative Localized Analysis Reveals Distinct Exosomal Protein-Specific Glycosignatures: Implications in Cancer Cell Subtyping, Exosome Biogenesis, and Function.

Pub. Date : 2020 Apr 22

PMID : 32239931






3 Functional Relationships(s)
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1 The integration of localized chemical remodeling and quantitative electrochemistry allows the proof-of-concept QLA examination of exosomal mucin 1 (MUC1)-specific terminal galactose/N-acetylgalactosamine (Gal/GalNAc). N-acetylgalactosaminuronic acid mucin 1, cell surface associated Homo sapiens
2 The integration of localized chemical remodeling and quantitative electrochemistry allows the proof-of-concept QLA examination of exosomal mucin 1 (MUC1)-specific terminal galactose/N-acetylgalactosamine (Gal/GalNAc). N-acetylgalactosaminuronic acid mucin 1, cell surface associated Homo sapiens
3 In combination with sialic acid (Sia) cleavage manipulation for the exposure of originally capped Gal/GalNAc, QLA has revealed distinct MUC1-specific sialylation capping ratios for MCF-7 and MDA-MB-231 exosomes, as well as when compared to parent cells. N-acetylgalactosaminuronic acid mucin 1, cell surface associated Homo sapiens