Pub. Date : 2020 Jun
PMID : 32238417
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stereoselective bupropion hydroxylation by cytochrome P450 CYP2B6 and cytochrome P450 oxidoreductase genetic variants. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by cytochrome P4502B6 (CYP2B6). | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by cytochrome P4502B6 (CYP2B6). | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Bupropion hydroxylation is the canonical in vitro and in vivo probe for CYP2B6 activity. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | Some CYP2B6 variants affect bupropion disposition. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | This investigation evaluated the influence of several human CYP2B6 and POR genetic variants on stereoselective bupropion metabolism, using an insect cell coexpression system containing CYP2B6, POR and cytochrome b5. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | CYP2B6-catalyzed bupropion hydroxylation is stereoselective. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 8 | Established concordance between human bupropion hydroxylation in vitro and in vivo, together with these new results, suggests additional CYP2B6 variants may influence human bupropion disposition. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 9 | Established concordance between human bupropion hydroxylation in vitro and in vivo, together with these new results, suggests additional CYP2B6 variants may influence human bupropion disposition. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 10 | SIGNIFICANCE STATEMENT: Bupropion pharmacokinetics, metabolism and clinical effects are affected by the CYP2B6*6 polymorphism. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 11 | Other expressed CYP2B6 polymorphisms had diminished (*5, *6, *7, *9, *19, *26) or defective (*16, *18) in vitro bupropion hydroxylation. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 12 | These CYP2B6 polymorphisms may portend diminished in vivo bupropion hydroxylation and predict additional clinically important variant alleles. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |