Pub. Date : 2020 May
PMID : 32237067
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small cell lung cancer cells. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | Moreover, p53 expression facilitated an increase in the LC3-II/ LC3-I ratio in response to paclitaxel, and PBK knockdown augmented paclitaxel-mediated p53 transcriptional activity. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | Moreover, p53 expression facilitated an increase in the LC3-II/ LC3-I ratio in response to paclitaxel, and PBK knockdown augmented paclitaxel-mediated p53 transcriptional activity. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 4 | Meanwhile, paclitaxel induced PBK-mediated p53 nuclear export and its subsequent ubiquitination in control cells, but not in PBK knockdown cells. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 5 | We conclude that PBK hampers paclitaxel-induced autophagic cell death by suppressing p53, suggesting a potential role of PBK in p53-mediated H460 cell death. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 6 | We conclude that PBK hampers paclitaxel-induced autophagic cell death by suppressing p53, suggesting a potential role of PBK in p53-mediated H460 cell death. | Paclitaxel | tumor protein p53 | Homo sapiens |