Title : Computational Design of an Allosteric Antibody Switch by Deletion and Rescue of a Complex Structural Constellation.

Pub. Date : 2020 Mar 25

PMID : 32232139






1 Functional Relationships(s)
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1 In previous studies, we began to explore this idea by introducing a deactivating tryptophan-to-glycine mutation in the domain-domain interface of a single-chain variable fragment (scFv), and then restoring activity by adding back indole to fit the designed cavity. Glycine immunglobulin heavy chain variable region Homo sapiens