Title : Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.

Pub. Date : 2020 Jul

PMID : 32229503






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Up to 90% of pediatric DIPGs harbor a somatic heterozygous mutation resulting in the replacement of lysine 27 with methionine (K27M) in genes encoding histone H3.3 (H3F3A, 65%) or H3.1 (HIST1H3B, 25%). dipinacoline glutamate H3 clustered histone 2 Homo sapiens