Title : Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice.

Pub. Date : 2020 Oct 5

PMID : 32227170






2 Functional Relationships(s)
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1 Investigating the role of Reg3B as a protective factor in colitis, we found that Reg3B-KO mice display increased inflammation and less crypt proliferation in the DSS colitis model. dss regenerating islet-derived 3 beta Mus musculus
2 Treatment of organoids exposed to DSS with Reg3B or propionate reversed the chemical injury with a loss of expression of the stem-cell marker Lgr5 and Olfm4. dss regenerating islet-derived 3 beta Mus musculus