Pub. Date : 2020 Mar 26
PMID : 32225074
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of POR*28 Polymorphisms on CYP3A5*3-Associated Variations in Tacrolimus Blood Levels at an Early Stage after Liver Transplantation. | Tacrolimus | cytochrome p450 oxidoreductase | Homo sapiens |
| 2 | Recently, it has been revealed that the POR*28 polymorphism affects the pharmacokinetics of tacrolimus in renal transplant patients. | Tacrolimus | cytochrome p450 oxidoreductase | Homo sapiens |
| 3 | In this study, we examined whether POR*28 as well as CYP3A5*3 polymorphism in Japanese recipients and donors would be another biomarker for the variation of tacrolimus blood levels in the recipients during the first month after living-donor liver transplantation. | Tacrolimus | cytochrome p450 oxidoreductase | Homo sapiens |
| 4 | In conclusion, to our knowledge, this is the first report suggesting that the POR*28 polymorphism is another biomarker for the tacrolimus oral dosage after liver transplantation in patients carrying CYP3A5*1 rather than CYP3A5*3/*3. | Tacrolimus | cytochrome p450 oxidoreductase | Homo sapiens |