Pub. Date : 2020 Mar 26
PMID : 32225068
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulation of CASP9 through NF-kappaB and Its Target MiR-1276 Contributed to TNFalpha-promoted Apoptosis of Cancer Cells Induced by Doxorubicin. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 2 | This opinion was supported by the following evidence: TNFalpha promoted the apoptosis of HeLa and HepG2 cells induced by doxorubicin (DOX). | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 3 | This opinion was supported by the following evidence: TNFalpha promoted the apoptosis of HeLa and HepG2 cells induced by doxorubicin (DOX). | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 4 | CASP9 was significantly upregulated and activated by TNFalpha in the DOX-induced cells. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 5 | Moreover, a known inhibitor of CASP9 activation significantly repressed the TNFalpha promotion of apoptosis induced by DOX. | Doxorubicin | tumor necrosis factor | Homo sapiens |
| 6 | The results also shed new light on the molecular mechanism underlying TNFalpha-promotion of cancer cells apoptosis induced by some anticancer drugs such as DOX. | Doxorubicin | tumor necrosis factor | Homo sapiens |