Title : Autophagy modulation altered differentiation capacity of CD146+ cells toward endothelial cells, pericytes, and cardiomyocytes.

Pub. Date : 2020 Mar 26

PMID : 32216836






2 Functional Relationships(s)
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1 METHODS: In this study, CD146+cells were enriched from the human bone marrow aspirates and trans-differentiated into mature endothelial cells, pericytes, and cardiomyocytes after exposure to autophagy stimulator (50-muM Met)/inhibitor (15-muM HCQ). Hydroxychloroquine melanoma cell adhesion molecule Homo sapiens
2 RESULT: Data revealed the modulation of autophagy factors, Beclin-1, P62, and LC3 II/I ratio in differentiating CD146+ cells after exposure to Met and HCQ (p < 0.05). Hydroxychloroquine melanoma cell adhesion molecule Homo sapiens