Title : Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy in tumors with PTEN loss.

Pub. Date : 2020 Mar 17

PMID : 32215185






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 AZD8186 significantly enhanced antitumor efficacy of anti-PD1 antibodies in the PTEN-deficient BP murine melanoma xenograft model, but not in the PTEN-wild-type CT26 xenograft model. AZD8186 programmed cell death 1 Mus musculus
2 However, AZD8186 has enhanced efficacy when combined with paclitaxel and anti-PD1 in vivo. AZD8186 programmed cell death 1 Mus musculus