Pub. Date : 2020
PMID : 32210718
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Western blot analysis showed that adenine reduced expression of cyclin A/D1 and cyclin-dependent kinase (CDK)2 and upregulated p53, p21, Bax, PUMA, and NOXA in HepG2 cell. | Adenine | tumor protein p53 | Homo sapiens |
| 2 | Moreover, adenine induced AMPK activation that was involved in the p53-associated apoptotic cascade in HepG2 cells. | Adenine | tumor protein p53 | Homo sapiens |
| 3 | Conclusions: These findings reveal that adenine reduces the cell growth of HepG2 and SK-Hep-1 but not Hep3B cells, attributing to the AMPK/p53-mediated S phase arrest and apoptosis. | Adenine | tumor protein p53 | Homo sapiens |
| 4 | It suggests that adenine has anticancer potential against p53-wild type HCC cells and may be beneficial as an adjuvant for HCC treatment. | Adenine | tumor protein p53 | Homo sapiens |