Title : Metformin treatment decreases the expression of cancer stem cell marker CD44 and stemness related gene expression in primary oral cancer cells.

Pub. Date : 2020 May

PMID : 32208194






2 Functional Relationships(s)
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1 Here, we attempt to find out the effect of metformin on cancer stem cell marker CD44 and stemness related transcription factors including OCT4, SOX2, NANOG, c-Myc and KLF4. Metformin Nanog homeobox Homo sapiens
2 RESULTS: Metformin showed downregulation in the gene expressions of stemness related transcription factors OCT4, SOX2, NANOG, c-Myc, and KLF4 in a dose-dependent as well as time-dependent manner. Metformin Nanog homeobox Homo sapiens