Title : Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds.

Pub. Date : 2020 Mar 23

PMID : 32205839






1 Functional Relationships(s)
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1 Using RNA sequencing, we found that plasminogen downregulated the expression of genes in the TLR, TNF, WNT, MAPK, and TGF-beta signaling pathways, and enhanced the anti-inflammatory effect of arachidonic acid, leading to significantly decreased inflammation and improved remodeling of granulation tissue compared with placebo treatment. Arachidonic Acid tumor necrosis factor Homo sapiens