Pub. Date : 2020 May
PMID : 32203934
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of docetaxel chemosensitivity by NR2F6 in breast cancer. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |
| 2 | Herein, both data mining and profiling analysis using clinical BCa biopsies showed that expression levels of the nuclear receptor subfamily 2, group F, member 6 (NR2F6), a recently characterized central transcription factor for cancer immune surveillance, were significantly downregulated in DTX-resistant BCa. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |
| 3 | Herein, both data mining and profiling analysis using clinical BCa biopsies showed that expression levels of the nuclear receptor subfamily 2, group F, member 6 (NR2F6), a recently characterized central transcription factor for cancer immune surveillance, were significantly downregulated in DTX-resistant BCa. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |
| 4 | In both genetically engineered cell models and patient-derived xenograft models, we provided evidence that BCa cells with insufficient NR2F6 expression were less responsive to DTX treatment. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |
| 5 | Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |
| 6 | Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |
| 7 | Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |
| 8 | Stable PDGFRB inhibition ameliorated NR2F6 deficiency-impaired response to DTX in BCa cells, indicating that NR2F6"s effect on DTX response is mediated, at least in part, through transcriptional repression of PDGFRB. | Docetaxel | nuclear receptor subfamily 2 group F member 6 | Homo sapiens |