Pub. Date : 2020 Mar 16
PMID : 32187976
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance. | Oxaliplatin | DExH-box helicase 9 | Homo sapiens |
| 2 | Blockage of phosphorylation by either PI3KK inhibitors or nonphosphorable mutants of DHX9 decreased the oxaliplatin-induced circCCDC66 expression and the ability to develop chemoresistant cells. | Oxaliplatin | DExH-box helicase 9 | Homo sapiens |
| 3 | Taken together, we demonstrated and linked the functional role of DHX9 phosphorylation to oncogenic circCCDC66 expression during the development of resistance to oxaliplatin, providing a mechanistic insight for the development of therapeutic strategies to recurring/chemoresistant colorectal cancer. | Oxaliplatin | DExH-box helicase 9 | Homo sapiens |