Title : Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy.

Pub. Date : 2020 Mar 12

PMID : 32184956

1 Functional Relationships(s)
Compound Name
Protein Name
1 Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors. Arginine proopiomelanocortin Homo sapiens