Title : Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy.

Pub. Date : 2020 Mar 12

PMID : 32184956

2 Functional Relationships(s)
Compound Name
Protein Name
1 The melanocortin receptors are stimulated by agonists (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) processed from the proopiomelanocortin (POMC) gene transcript and possess a common His-Phe-Arg-Trp tetrapeptide sequence critical for receptor activation. Histidine proopiomelanocortin Homo sapiens
2 Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors. Histidine proopiomelanocortin Homo sapiens