Pub. Date : 2020 Mar 12
PMID : 32184956
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The melanocortin receptors are stimulated by agonists (alpha-MSH, beta-MSH, gamma-MSH, and ACTH) processed from the proopiomelanocortin (POMC) gene transcript and possess a common His-Phe-Arg-Trp tetrapeptide sequence critical for receptor activation. | Histidine | proopiomelanocortin | Homo sapiens |
| 2 | Herein, 12 single nucleotide polymorphisms (SNPs) deposited into the Variation Viewer database within the His-Phe-Arg-Trp sequences of ACTH/alpha-MSH, beta-MSH, and gamma-MSH were substituted into tetrapeptide scaffolds to examine the in vitro signaling effects of these polymorphisms at the cloned melanocortin receptors. | Histidine | proopiomelanocortin | Homo sapiens |