Pub. Date : 2020 May
PMID : 32169822
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we demonstrate that the protein Frataxin (FXN) is a key regulator of ferroptosis by modulating iron homeostasis and mitochondrial function. | Iron | frataxin | Homo sapiens |
| 2 | In the present study, we demonstrate that the protein Frataxin (FXN) is a key regulator of ferroptosis by modulating iron homeostasis and mitochondrial function. | Iron | frataxin | Homo sapiens |
| 3 | Suppression of FXN expression specifically repressed the proliferation, destroyed mitochondrial morphology, impeded Fe-S cluster assembly and activated iron starvation stress. | Iron | frataxin | Homo sapiens |
| 4 | Suppression of FXN expression specifically repressed the proliferation, destroyed mitochondrial morphology, impeded Fe-S cluster assembly and activated iron starvation stress. | Iron | frataxin | Homo sapiens |
| 5 | Moreover, suppression of FXN expression significantly enhanced erastin-induced cell death through accelerating free iron accumulation, lipid peroxidation and resulted in dramatic mitochondria morphological damage including enhanced fragmentation and vanished cristae. | Iron | frataxin | Homo sapiens |
| 6 | Vice versa, enforced expression of FXN blocked iron starvation response and erastin-induced ferroptosis. | Iron | frataxin | Homo sapiens |
| 7 | More importantly, pharmacological or genetic blocking the signal of iron starvation could completely restore the resistance to ferroptosis in FXN knockdown cells and xenograft graft in vivo. | Iron | frataxin | Homo sapiens |